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教师风采——黎姿茵

所属新闻组:营养与食品卫生学系

基本信息:

医学博士,讲师,营养与食品卫生学系

Emailliziyin@gdpu.edu.cn

办公电话:13265051337


【教育背景】

2016.09-2022.06,南方医科大学公共卫生学院,营养与食品卫生学,医学博士

2012.09-2016.06,广东医科大学公共卫生学院,卫生检验,理学学士


【学术及工作经历】

2022.07-2025.08,南方医科大学附属第十医院,博士后

2019.12-2020.03,贝尔法斯特女王大学全球食品安全研究所生命科学学院,进修访学


【研究兴趣领域】

1.食品污染物危害机制与防控

2.食品营养与功效评价


【招生方向】

105300营养与食品卫生(公共卫生硕士,专业学位)



【科研项目】

主持

1. 国家自然科学基金委员会, 青年基金项目,Nrf2/JNK 调控铁自噬介导的铁 死亡在镉致肾损伤中的作用及机制研究,2024-012026-12

2. 中国博士后科学基金第74批面上资助,PPAR-γ调控TXNIP/NLRP3在镉致肾损伤中的作用及机制研究,2023-112024-08

3. 东莞市科学技术局, 2023年东莞市社会发展科技项目(高水平医院建设专项), 夏枯草提取物对镉致肾损伤的干预作用及机制研究, 2023-012025-12

4. 广东省基础与应用基础研究基金委员会, 区域联合基金-青年基金项目, 基于NLRP3炎症小体信号探讨镉致肾损伤机制及金丝桃苷的干预效应,2022-102025-09


主要参与

1. 国家自然科学基金委员会, 面上项目,α-乳白蛋白姜黄素纳米复合物通过 PepT1-溶酶体提高生物利用度对镉致动脉粥样硬化的干预作用机制研究,2024-01 2027-12

2. 国家重点研发计划基础科研条件与重大科学仪器设备研发专项“基于化妆品和生物制品等产品检验的动物实验替代技术研究”,2022-11 2026-10

3. 广东省科技厅, 广东省重点领域研发计划项目, 食用色素及包装材料的危害识别与风险评价技术, 2019-012022-12

【部分代表性论文】

1. Li Z#, Li W#, Xv F, Lai Y, Yin X, Xiao X, Xing X* and Yang X*, Integrated microbiome and metabolomic analysis uncover the amelioration mechanisms of Prunella vulgaris L. polysaccharides on gut health of ulcerative colitis. Food Science and Human Wellness, 2025.

2. Xv F#, Li Z#et al., Comprehensive analysis of mode of action for cadmium-induced renal tubular dysfunction: A case study integrating high throughput sequencing, targeted cellular assays, and human data. Environment international. 2025.

3. Li Z#, He Q#, Xu F, Yin X, Guan Z, Song J, He Z, Yang X# and Situ C#. Exploring the Antibacterial Potential and Underlying Mechanisms of Prunella vulgaris L. on Methicillin-Resistant Staphylococcus aureus. Foods. 2024;13.

4. Chen Y, Xu F, Xiao X, Chi H, Lai Y, Lin X, Li Q, Song J, Wu W,Li Z* and Yang X*. Assessment of osteopontin as an early nephrotoxicity indicator in human renal proximal tubule cells and its application in evaluating lanthanum-induced nephrotoxicity. Ecotoxicology and environmental safety. 2024;271:115928.

5. Li Z, Liao W, Yin X, Liu L, Zhao Z, Lu X, Xu F, Lin X, Chen Y, Song J, He Z, Wei Q, Wu W, Wu Y* and Yang X*. Hyperoside attenuates Cd-induced kidney injury via inhibiting NLRP3 inflammasome activation and ROS/MAPK/NF-κB signaling pathway in vivo and in vitro. Food and chemical toxicology. 2023;172:113601.

6. Li Z et al., Cadmium induces renal inflammation by activating the NLRP3 inflammasome through ROS/MAPK/NF-κB pathway in vitro and in vivo. Arch Toxicol. 2021, 1-17

7. Li Z et al., Frozen kinetics models for sensory, chemical, andmicrobial spoilage of preserved razor clam (Sinonovacula constricta) at different temperatures. Int J Food Eng. 2020; 16(11): 20190288.

8. Li W#, Li Z#et al., Oenothein B boosts antioxidant capacity and supports metabolic pathways that regulate antioxidant defense in Caenorhabditis elegans. Food & Function, 2020, 11, 9157-9167. Cao Y#, Li Z# (co-first author) et al., The use of proteomic technologies to study molecular mechanisms of multidrug resistance in cancer. Eur J Med Chem, 2019; 162, 423-434.

9. Luo S#,Li Z# et al., Sodium butyrate induces autophagy in colorectal cancer cells through LKB1/AMPK signaling. J Physiol Biochem,2019; 75, 53-63.

10. He Q*, Li Z et al., A superchilling storage–ice glazing (SS-IG) of Atlantic salmon (Salmo salar) sashimi fillets using coating protective layers of Zanthoxylum essential oils (EOs). Aquaculture, 2020, 514: 734506. (IF=3.9, 中科院1)

11. Tan L, Yang J, He Z, Wan Y,Li Z, Song J, Zhang W* and Yang X*. Inhibitory effects of extracts from Prunella vulgaris on biofilm formation of Staphylococcus aureus. Microbial pathogenesis. 2025;205:107694.

12. Xu F, Chen Y, Lin X, Zhong A, Zhao M, Li Y, Li Z, Lai Y, Song J, Pan J, Cai Z, Liang X, Liu Z, Wu Y, Wu W and Yang X*. Bioaccessibility and bioavailability assessment of cadmium in rice: In vitro simulators with/without gut microbiota and validation through in vivo mouse and human data. The Science of the total environment. 2024;953:175980.

13. Mo L, Chen L, Wan Y, Huang H, Mo L, Zhu W, Yang G,Li Z, Wei Q, Song J and Yang X*. An aqueous extract of Prunella vulgaris L. ameliorates cadmium-induced bone loss by promoting osteogenic differentiation in female rats. Food and chemical toxicology . 2023;180:114005.

14. Li W, Chen H, Chen H,Li Z, Hu W, Zhou Q, Xu B, Wang Y*, Xing X*. Andrias davidianus bone peptides alleviates hyperuricemia-induced kidney damage in vitro and in vivoFood Science and Human Wellness, 2022.9250157.

15. 李诗妤, 麦燕珊, 李晓琦, 赵汝珣, 阮译萱, 尹欣欣,黎姿茵*,杨杏芬*. 五大科植物提取物对痤疮丙酸杆菌的抑制作用及机制研究进展。华南预防医学. 2024;50:587-590.

16. 林秀琴, 陈颖思, 黎姿茵, 徐飞飞, 万思雨, 赵晓晗, 宋佳, 吴炜亮,杨杏芬#. 稀土元素镧代谢动力学及对血液元素谱的影响。中国食品卫生杂志. 2023;35:1152-1159.

【专利】

1. 杨杏芬,黎姿茵,司徒琛,池慧钦,王延。夏枯草联用抗生素在制备抗耐多药金黄色葡萄球菌药物中的应用。专利号: ZL 202010774618.9

【获奖情况】

1. NLRP3炎症小体在镉致肾脏炎症过程中的作用及机制研究. 广东省毒理学会2021年度会员代表大会暨第一届青年学者和研究生论坛, 2021.(口头报告,获优秀论文奖)

2. Li Z et al., The role and mechanism of NLRP3 inflammasome in cadmium-induced kidney inflammation. 2021第九届亚洲毒理学大会暨中国毒理学会第八次中青年科技论坛. (优秀壁报奖)

【社会兼职】

1. 广东省诱变剂学会第七届理事会理事

2. 广东省毒理学会第二届青年委员会委员